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Associate Scientist - DMPK

Bristol-Myers Squibb Company

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Princeton, NJ
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Job Description

As posted by the hiring company

Job Overview:

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Nonclinical Research and Development (NCRD) is an integrated function with responsibility for characterizing nonclinical safety and disposition characteristics of the entire BMS Research and Development pipeline programs, with critical role from early discovery to submission of marketing authorization applications. We utilize our deep expertise in toxicology/pathology, ADME, PK/PD and Bioanalytics in all modalities (small and large molecules, cellular therapies and other novel modalities) to collaborate with peer R&D functions to identify and solve issues, discover high quality drug candidates, enable their clinical development and successful marketing authorizations across the globe.

Position Summary:

We are seeking a highly enthusiastic, self-motivated, exceptional scientist to join our group as a Associate Scientist in drug metabolism & pharmacokinetics (DMPK) at our Princeton, NJ site. The role is in the Pharmaceutical Candidate Optimization (PCO) department that encompasses broad support for Discovery programs with expertise in DMPK, toxicology, pharmaceutics and bioanalytical sciences.

Key Responsibilities:

In this role, the candidate will provide drug metabolism support for Discovery programs, and he/she will be responsible for designing and conducting mechanistic in vitro and in vivo metabolism studies to characterize the metabolic pathways, evaluate metabolism kinetics and resolve issues to drive impact in our discovery efforts. There will be a major emphasis on working with Discovery project teams at our Princeton, NJ site, but the candidate will be expected to contribute/collaborate with program science and strategy across the Discovery portfolio.

Basic Qualifications:

  • Bachelor's Degree and 2+ years of academic and / or industry experience

Preferred Qualifications:

  • M.S. in pharmacokinetics, drug metabolism, medicinal chemistry or related discipline with a minimum of 5 years of relevant industrial experience or BS with 8+ years of relevant industrial experience.

  • Hands-on experience in profiling and identification of drug metabolites in in vitro (microsomes, S9, hepatocytes etc.) and in vivo biological matrices (plasma, urine, bile etc.) using LC-HRMS.

  • Independently design, develop, and execute drug metabolism studies.

  • Experience interpreting mass spectral data to make structural assignments and strong trouble shooting skills for LC-HRMS is required.

  • A good understanding of ADME and pharmacokinetic principles and experience in supporting drug discovery as a drug metabolism contributing scientist.

  • Experience with small molecule DMPK strategies is essential, and experience with other novel modalities is desired.

  • In addition, a strong interest in evaluating new technologies and designing new assays to enhance our capabilities and support innovation within the group is desired.

  • The ideal candidate must possess excellent oral and written communication skills and be a team player.

  • Have the ability to collaborate and build relationships with other disciplines in PCO (discovery toxicology, discovery pharmaceutics and bioanalytical research) for issue resolution and program advancement is essential.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.