Job Description

Associate Principal Scientist, General Medicine Therapeutic Areas Biomarker Lead

Job Description

Translational Biomarkers (TB) is responsible for the development and validation of clinical biomarkers, and their end-to-end strategic utilization across all therapeutic areas and all phases of clinical development at our Company's Research laboratories. TB therapeutic area biomarker leads actively collaborate with colleagues in discovery and clinical development to ensure fit-for-purpose biomarker strategies are in place to address key clinical questions and enable facile decision-making to support our pipeline.

The Biomarker Leads group within the TB organization is seeking a highly motivated candidate to join our team. The individual will play a critical role in the design, delivery, and execution of biomarker plans for our Company's early and late phase clinical trials in the General Medicine therapeutic areas including but not limited to cardiometabolic disorders.

The ideal candidate for this Associate Principal Scientist position should have strong expertise in translational science and laboratory medicine, with demonstrated experience applying biomarkers to assess drug activity and patient response to inform therapeutic decision making. In addition, the individual should have a strong desire to operate in a highly collaborative and matrixed environment to address unmet patient needs in complex, multi-organ diseases.

The individual will have the following responsibilities:

Design and implement biomarker strategies for early and late-stage clinical programs.
Lead clinical biomarker sub-teams as part of program development teams and represent the functional area during governance interactions.
Liaise with subject matter experts to identify and effectively implement target engagement, pharmacodynamic, proof-of-mechanism, and precision medicine biomarkers for clinical phase programs.
Facilitate the adoption of innovative technologies and methodologies for biomarker identification and analysis, grounded in disease pathophysiology and aligned with therapeutic mechanisms of action.
Participate in the formulation of testable hypotheses for biomarker analyses and facilitate interpretation of results to ensure meaningful and accurate conclusions are drawn.
Contribute to biomarker-related presentations, publications, and engagements, both internally and externally.

Position Qualifications:

Education Minimum Requirement:

BS, MS, or Ph.D. in a life sciences discipline (Biochemistry, Immunology, Molecular Pathology, Cell Biology, or related field).

Required Experience and Skills:

Ph.D. and 5 years OR MS and 8+ years OR BS and 12+ years of experience in the biotech or pharmaceutical industry, specifically in translational or biomarker sciences.
Excellent interpersonal, project leadership, verbal, and written communication skills.
Strong scientific rigor, analytical and problem-solving abilities, with attention to detail and the ability to interpret complex data.

Preferred Qualifications:

Demonstrated experience supporting translational research in cardiometabolic disorders, including the development and integration of vascular, inflammatory, metabolic, and/or fibrosis biomarkers to inform patient stratification, pharmacodynamic assessment, or mechanistic understanding of disease biology.
Contributions to the scientific community through publications, presentations, or scientific consortia.
Proficiency in applying omics technologies and/or computational approaches (e.g., AI/ML, bioinformatics, digital pathology analytics) to extract, integrate, and interpret biomarker data is advantageous.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

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US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights

EEOC GINA Supplement

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.

Expected US salary range:

$126,500.00 - $199,100.00

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Hybrid

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

n/a

Required Skills:

Academic Conferences, Academic Conferences, Bioanalytical Analysis, Bioanalytical Assays, Bioanalytical Techniques, Biochemical Assays, Biomarker Development, Biomarker Identification, Biomarkers, Biopharmaceutical Industry, Cardiometabolic, Clinical Judgment, Clinical Testing, Clinical Trials Analysis, Creativity, Data Analysis, Detail-Oriented, Drug Discovery Development, Drug Discovery Research, Ethical Compliance, Fibrosis, Immunohistochemistry (IHC), In Vivo Pharmacology, Mass Spectrometry Analysis, Metabolic Diseases {+ 12 more}

Preferred Skills:

Drug Discovery Process

Job Posting End Date:

06/3/2025

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.