Associate Principal Scientist (Associate Director) - Health Economics and Decision Sciences - Oncology

Merck Cherokee

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Boston, MA

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Job Description

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science”, great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

We have an exciting opportunity for a new Associate Principal Scientist to join our Oncology health economic modeling team in the Economic and Data Sciences group. The preferred location is in West Point, PA; while alternate locations in the US (Philadelphia, PA, Rahway, NJ and Boston, MA) and UK (London) are possible as well.

The Health Economic and Decision Sciences (HEDS) department is part of our company's Biostatistics and Research Decision Sciences (BARDS) organization. BARDS is responsible for strategic design and analysis to enable informed decision making in the discovery, development and delivery of our company's innovative products, and is a leader in quantitative scientific methodology and its application to enable the targeting, discovery, development, manufacturing, and marketing of drugs and vaccines for the benefit of patients and global public health. In collaboration with internal and external partners, the BARDS-HEDS department specifically provides strategic and technical leadership to enable patient access, measure and quantify the value of our company's products, inform internal and external decisions, and shape methodology and external health policy and practice. This position will focus on health economic modeling for oncology products.


Under the direction of a HEDS Senior Director, the Associate Principal Scientist provides strategic development and use of industry-leading predictive and economic models to enhance our understanding of disease and to quantify and communicate the value of our oncology products to patients, providers, and payers.

  • Serve as the BARDS HEDS lead for one or more value evidence teams to develop health economic, disease, and predictive models to enable business insights for the product.

  • Utilize discovery, real world evidence, clinical trial and published data, and publicly available information and tools to provide economic and integrated models to answer key questions in all phases of drug and vaccine development – Phase I through loss of data exclusivity.

  • Advance the use of integrated quantitative approaches, focusing on economic, disease, and predictive modeling and simulation in partnership with other internal groups and external organizations.

  • Development and maintenance of health quality global health economic models and tools in-house or in collaboration with external vendors to provide critical business insights and fully demonstrate the value of our company’s products.

  • Support and training of HEDS models and tools to support country/regional team adaptations and communications with external stakeholders.

  • Dissemination of health economic data via presentations at congresses and publications in scientific journals.

  • 'Work closely with external collaborators (clinical/economic thought leaders, payer/HTA experts, alliance partners) and internal teams (including those represented on the Value Evidence Subteam or VEST) to ensure that new methodologies, models and advanced analytics are fully utilized for our products.

  • Maintain awareness of external data, modeling methodologies and IT tools to collaborate across relevant internal stakeholders to enhance our company's capabilities in health economic modeling, simulation, and data visualization.

  • Partner in defining and implementing the HEDS vision and strategy to develop an innovative, world class Center of Excellence in data science as well predictive and economic modeling.

  • Ensure sharing of work product and relevant best practices across our company's enterprise.


  • PhD (preferred) or Masters Degree, in Health Economics, Biostatistics, Health Services Research, Actuarial Sciences or a closely related, quantitative field

Required Experience and Skills:

  • Relevant experience in health economics and outcomes research (HEOR) of 3 or more years beyond PhD (or 5 or more years beyond Masters degree)

  • Knowledge and experience in economic evaluation of oncology drugs and interventions

  • Expertise and solid hands-on experience in the conceptualization, design, development and dissemination of health economic model approaches to enable internal and external decisions

  • Track record of submissions to Health Technology Assessment bodies and research publications in conferences and peer-reviewed journals

  • Strong interpersonal, organizational and communication skills with ability to interact with individuals from a variety of disciplines

  • Understanding of the market access environment and challenges in the US and key international markets

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in health services, customer facing commercial, or research based roles, will be required to be fully vaccinated as a condition of employment.

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