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2022 GMU CMC Co-Op Purification Process Development

Principia Biopharma, Inc.

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Waltham, MA
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Job Description

As posted by the hiring company

Job Overview:

Position Overview/Department Description

The Genomic Medicine Unit (GMU) within Sanofi is responsible for the design and optimization of viral vector manufacturing processes and platforms. We chase the miracles of science through exploration of novel technologies to enable better characterization of our next-generation production platforms and to enable high-dose gene therapy programs. This 6-month position centers on viral vector purification processes but will interface with a broader team of vector and cell line engineering, upstream process development, analytics, and clinical manufacturing support.

A successful candidate in this role will be engaged in actively learning new techniques, independently performing experiments, analyzing and presenting results, and collaborating with different functions to understand the cross-functional nature of decision-making. Experience in protein characterization, high-throughput, engineering and data analysis, analytical techniques, and/or viral vector purification is preferred. Project topic will be commensurate with level of previous experience.

Key Responsibilities

  • Design, execute, and analyze viral vector purification experiments.

  • Perform analytical characterization of samples and analyze results.

  • Work with cross-functional team for feedback and present findings.

  • Contribute to technical reports and/or external publications if appropriate to project topic and level of experience.

Basic Qualifications

  • Currently pursuing a Master's or Bachelor's study in biological sciences, genetic engineering/ engineering sciences with relevant study experience.

  • Understanding of cell engineering, molecular biology, virology and immunology concepts.

  • Knowledge and understanding of technologies and operations such as:

    • Chromatography, tangential flow filtration, normal flow filtration, and/or viral clearance and inactivation

    • Advanced analytical tools to characterize protein and viral vectors

  • Work under minimal supervision and function within a collaborative, team-oriented environment.

  • Ability to work in Biosafety Level 2, follow safe lab procedures, and maintain good laboratory practices (GLPs) including detail-oriented laboratory notebook documentation.

Preferred Qualifications

  • Experience with viral vector purification and characterization.

  • Experience with SEC-HPLC, DLS, ddPCR/qPCR, Western blot, ELISA, FACS, immunoassays, spectroscopic and bioassay techniques.

  • Experience with AKTA automated chromatography instruments, high-throughput liquid handlers, and automated filtration instruments.

  • Experience with protein sequences and tools such as NanoSight 3000, Caliper LabChip GXII, Multi-Angle DLS (MADLS), ForteBio Octet, or similar instruments.

  • Basic understanding of the principles of Quality by Design and ability to apply DOE to downstream development.

  • Excellent communication skills and ability to build cross-functional relationships.

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.